Product Description: Denosumab is a human monoclonal antibody binding to, and inhibiting, the receptor activator of RANKL (TNFSF11). Denosumab can reduce the risk of vertebral, nonvertebral and hip fractures[1], also has anti-cancer activity[2].
Applications: Cancer-programmed cell death
Formula: C6404H9908N1724O2004S50
References: [1]Moen MD, et al. Denosumab: a review of its use in the treatment of postmenopausal osteoporosis. Drugs Aging. 2011;28(1):63-82./[2]Chawla S, et al. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019;20(12):1719-1729.
CAS Number: 615258-40-7
Molecular Weight: 144716.86
Compound Purity: 99.10
Research Area: Cancer
Solubility: H2O
Target: NF-κB