Empasiprubart, CAS 2579031-19-7

Product Description: Empasiprubart (ARGX-117) a humanized inhibitory monoclonal antibody against complement C2. Empasiprubart prevents the formation of the C3 proconvertase and inhibits classical and lectin pathway activation upstream of C3 activation through binding to the Sushi-2 domain of C2. Empasiprubart exhibits pH- and calcium-dependent target binding. Empasiprubart prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants[1].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Inge Van de Walle, et al.  ARGX-117, a therapeutic complement inhibiting antibody targeting C2. J Allergy Clin Immunol. 2021 Apr;147(4):1420-1429.e7.

CAS Number: 2579031-19-7

Molecular Weight: N/A

Compound Purity: 97.93

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-P990025-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P990025-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK