Flotetuzumab, CAS 1664355-28-5

Product Description: Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule.Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML)[1][2].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Chichili GR, et al. A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates. Sci Transl Med. 2015 May 27;7(289):289ra82. /[2]Barwe SP, et al. Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia. J Clin Med. 2022 Feb 28;11(5):1333.

CAS Number: 1664355-28-5

Molecular Weight: N/A

Compound Purity: 98.71

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: CD3

• SKU: MEXHY-P99623-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99623-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Conjugate: Unconjugated