Garadacimab, CAS 2162134-62-3

Product Description: Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting activated factor XII (FXIIa). Garadacimab has the potential for hereditary angioedema research[1].

Applications: Neuroscience-Neuromodulation

Formula: N/A

References: [1]Dipti Pawaskar, et al. Pharmacokinetic/pharmacodynamic modeling for dose selection for the first-in-human trial of the activated Factor XII inhibitor garadacimab (CSL312). Clin Transl Sci. 2022 Mar;15(3):709-720. /[2]Helen Cao, et al. Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation. J Allergy Clin Immunol. 2018 Oct;142(4):1355-1358.

CAS Number: 2162134-62-3

Molecular Weight: N/A

Compound Purity: 95.00

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Factor Xa

• SKU: MEXHY-P99631-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99631-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Conjugate: Unconjugated