Inbakicept, CAS 2135939-52-3

Product Description: Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells[1].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Rosario M, et al. The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas. Clin Cancer Res. 2016 Feb 1;22(3):596-608.

CAS Number: 2135939-52-3

Molecular Weight: N/A

Compound Purity: 98.95

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Interleukin Related

• SKU: MEXHY-P99661-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99661-10
• Package Unit: 10 mg
• Quantity Unit: STK
• Conjugate: Unconjugated