Product Description: Ipafricept (OMP-54F28; FZD8-Fc) is the first class of recombinant fusion proteins, consisting of the extracellular portion of the human fried-8 receptor fused to the Fc fragment of human IgG1 binding to the Wnt ligand. Ipafricept shows solid tumor inhibition activity, with well tolerance[1].
Applications: Cancer-programmed cell death
Formula: N/A
References: [1]Jimeno A, et al. A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Dec 15;23(24):7490-7497.
CAS Number: 1391727-24-4
Molecular Weight: N/A
Compound Purity: 99.80
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Wnt