Lorukafusp alfa, CAS 2131168-99-3

Product Description: Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity[1].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Suzanne Shusterman, et al. Antitumor Activity and Tolerability of hu14.18-IL2 with GMCSF and Isotretinoin in Recurrent or Refractory Neuroblastoma: A Children's Oncology Group Phase II Study. Clin Cancer Res. 2019 Oct 15;25(20):6044-6051.

CAS Number: 2131168-99-3

Molecular Weight: N/A

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-P990076-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P990076-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK