Pabinafusp alfa, CAS 2140211-48-7

Product Description: Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice[1].

Applications: Neuroscience-Neuromodulation

Formula: N/A

References: [1]Morimoto H, et al. Dose-dependent effects of a brain-penetrating iduronate-2-sulfatase on neurobehavioral impairments in mucopolysaccharidosis II mice. Mol Ther Methods Clin Dev. 2022 May 10;25:534-544.

CAS Number: 2140211-48-7

Molecular Weight: N/A

Compound Purity: 97.49

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Transferrin Receptor

• SKU: MEXHY-P99797-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99797-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Conjugate: Unconjugated