Seribantumab, CAS 1334296-12-6

Product Description: Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models[1].

Applications: Cancer-Kinase/protease

Formula: N/A

References: [1]Odintsov I, et al. The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions. Clin Cancer Res. 2021 Jun 1;27(11):3154-3166.

CAS Number: 1334296-12-6

Molecular Weight: 143.2 (kDa)

Compound Purity: 95.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;EGFR

• SKU: MEXHY-P99268-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99268-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK