Sudubrilimab

Product Description: Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment[1].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Gao ZZ, et, al. Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein. Protein Expr Purif. 2022 Jan;189:105973.

Molecular Weight: N/A

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: PD-1/PD-L1

• SKU: MEXHY-P99963-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99963-0
• Package Unit: Get quote
• Quantity Unit: STK
• Conjugate: Unconjugated