Teprotumumab, CAS 1036734-93-6

Product Description: Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: N/A

References: [1]Chen H, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014 Sep;99(9):E1635-40.

CAS Number: 1036734-93-6

Molecular Weight: N/A

Compound Purity: 99.45

Research Area: Endocrinology

Solubility: 10 mM in DMSO

Target: IGF-1R;TSH Receptor

• SKU: MEXHY-P99165-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99165-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK