Product Description: XmAb 5592 is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP)[1].
Applications: Cancer-programmed cell death
Formula: N/A
References: [1]Tai YT, et, al. Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function. Blood. 2012 Mar 1;119(9):2074-82.
CAS Number: 1221901-33-2
Molecular Weight: N/A
Compound Purity: 99.51
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Others