Formulation: 200 µg of peptide in TBS, pH 7.4, containing 0.1% BSA, and 0.02% sodium azide
Shelf life (days): 1095
Notes: Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages.{13210} This receptor is also expressed in brain, liver, lung, and kidney tissues.{13210,17561} Chemerin (TIG2) has been identified as the natural ligand for this receptor.{17560} Resolvin E1 has also been identified as a ligand for CMKLR1; acting to dampen cellular responses to inflammation.{13210,17558,17559} Chemerin is an 18 kDa protein that plays a role in immunity, inflammation, chemotaxis, and has been identified as an adipokine.{17561,15020,17557} Human CMKLR1 shares 80% sequence homology with its murine ortholog.{17560} The human receptor exists in two isoforms, differing only by two amino acids due to a premature stop codon. Isoform one has 363 amino acids and an expected molecular weight of 42.3 kDa. Cayman’s CMKLR1 polyclonal antibody recognizes the C-terminal region of the protein and cell permeabilization is recommended prior to whole cell staining.
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