Formulation: 200 µg of peptide
Shelf life (days): 1095
Notes: ChREBP (carbohydrate response element-binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NSL) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine-zipper-like (Zip-like) domain.{12881} ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney, white and brown adipose tissue.{12882} Under basal conditions ChREBP is localized in the cytosol and upon high glucose stimulation the protein is translocated into the nucleus following its dephosphorylation of phospho-Ser196.{12881} Murine ChREBP is 864 amino acids in length with an estimated molecular weight of about 95 kDa. Cayman’s ChREBP polyclonal antibody detects a specific band at 100 kDa in tissues and cells such as liver, white fat, and HepG2 cells.
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