Presentation: Sterile solution in PBS, pH 7.4, 10% Glycerol.
Description: The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.
Concentration: 0.48 mg/ml
Recommended Storage: Store at less than -20°C for up to 6 months. Avoid freeze-thaw cycles.
Protein Tag: 6His, N-terminus
Protein Type: Recombinant
Purification: Greater than 85 % as determined by reducing SDS-PAGE.
Predicted Molecular Weight: 62.9 kDa
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