Formulation: 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Shelf life (days): 1095
Notes: To be used in conjunction with Cayman’s CysLT2 Receptor (C-Term) Polyclonal Antibody (Catalog No. 120550) to block protein-antibody complex formation during analysis for CysLT2 Receptor (C-Term) · The cysteinyl leukotrienes (cysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.{3956,4157,7174,8519} LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2.{3956} Cloning of the human CysLT2 receptor reveals it is a 346 amino acid protein with 38% homology to the CysLT1 receptor.{2069,9059} The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTC4 = LTD4 >> LTE4.{2069} The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.{2069,3783}
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