Description: EGF Receptor,also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. It binds to a subset of EGF family ligands, including EGF, TGF-alpha, amphiregulin, EPGN, BTC, EREG and HBEGF. Ligand binding triggers receptor homo- or hetero-dimerization, which induces downstream kinase activation, tyrosine phosphorylation and cell signaling. EGF receptor signaling has been shown to regulate cell proliferation, differentiation, motility and apoptosis.
Presentation: Lyophilized from PBS
Protein Tag: His, C-Terminal
Protein Type: Recombinant
Reconstitution Instructions: Reconstitute in sterile ddH20 or PBS at 100 ug/ml.
Purification: Greater than 95% by SDS-PAGE
Predicted Molecular Weight: 95-115 kDa (SDS-PAGE)
Synonyms: EGFR, EGF Receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1
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