Description: Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds the EGF receptor with higher affinity and is thus more mitogenic, probably due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin.
Presentation: Lyophilized from PBS
Protein Type: Recombinant
Reconstitution Instructions: Reconstitute in ddH2O or PBS at 100 µg/ml.
Purification: Greater than 95% by SDS-PAGE and HPLC
Predicted Molecular Weight: 12-14 kDa (SDS-PAGE)
Synonyms: HBEGF, Dtr, DTS, DTSF, HEGFL, Diphtheria Toxin Receptor
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