Description: KLK2 is a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. KLK2 is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. Recombinant human KLK2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Presentation: 20 mM Tris-HCl, pH 8.0, 0.4 M Urea, 10% Glycerol
Protein Tag: His
Protein Type: Recombinant
Purification: Greater than 90% by SDS-PAGE
Synonyms: KLK2, Glandular kallikrein 2, Glandular kallikrein-1, HGK-1, Kallikrein 2, prostatic, Kallikrein-2, Kallikrein-related peptidase 2, KLK2A2, Tissue kallikrein-2
Concentration: 1 mg/ml
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