MARK1 Blocking Peptide (C terminal)

Description of Target: MARK1 is a serine/threonine-protein kinase which is involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. It is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also it acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Product Format: Lyophilized powder

Protein Size: 645

• SKU: AVIAAP74047-100
• Manufacturer: Aviva Systems Biology
• Manufacturer SKU: AAP74047-100UG
• Green Labware: No
• Package Unit: 100µg
• Quantity Unit: STK
• Application: Western Blotting
• Human Gene ID: 4139