Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: FBXO33 is the substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1.Members of the F-box protein family, such as FBXO33, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FBXO33
Key Reference: Jin,J., (2004) Genes Dev. 18 (21), 2573-2580
Molecular Weight: 62kDa
Peptide Sequence: Synthetic peptide located within the following region:
VIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: F-box only protein 33
Protein Size: 555
Purification: Affinity Purified