Ldlrap1 Antibody - C-terminal region : FITC

Conjugation: FITC: Fluorescein Isothiocyanate

Description of Target: Ldlrap1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). It may be required for LDL binding and internalization but not for receptor clustering in coated pits. It may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. Ldlrap1 may also be involved in the internalization of other LDLR family members. Ldlrap1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Ldlrap1

Molecular Weight: 29kDa

Peptide Sequence: Synthetic peptide located within the following region: APLSTVSANTNNVDETPRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQ

Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.

Protein Size: 264

Purification: Affinity Purified

• SKU: AVIARP55309_P050FITC
• Manufacturer: Aviva Systems Biology
• Manufacturer SKU: ARP55309_P050-FITC
• Green Labware: No
• Package Unit: 100μl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Rabbit, Dog (Canine), Guinea Pig, Cow (Bovine), Zebrafish, Horse (Equine)
• Clonality: Polyclonal
• Application: Western Blotting
• Human Gene ID: 100017
• Host: Rabbit