Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: RHOC Is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. RHOC is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of RHOC is associated with tumor cell proliferation and metastasis.This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RHOC
Key Reference: Sousa,J.F. (er) BMC Cancer 8, 19 (2008)
Molecular Weight: 22kDa
Peptide Sequence: Synthetic peptide located within the following region:
VPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Rho-related GTP-binding protein RhoC
Protein Size: 193
Purification: Affinity Purified
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