Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1
Key Reference: Salat,D., (2008) Mol. Cell. Biol. 28 (10), 3502-3512
Molecular Weight: 64kDa
Peptide Sequence: Synthetic peptide located within the following region:
RQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: cDNA, FLJ92968, highly similar to Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 1, mRNA EMBL BAG35486.1
Protein Size: 577
Purification: Affinity Purified
English
Deutsch
