Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: SCP2 protein is thought to be an intracellular lipid transfer protein. SCP2 is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis.This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SCP2
Key Reference: Stanley,W.A., (2007) Arch. Biochem. Biophys. 461 (1), 50-58
Molecular Weight: 35kDa
Peptide Sequence: Synthetic peptide located within the following region:
NHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILAProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Non-specific lipid-transfer protein
Protein Size: 322
Purification: Affinity Purified
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