Conjugation: HRP: Horseradish Peroxidase
Description of Target: Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. SPO11 is similar in sequence and conserved features to the yeast meiotic recombination protein. It belongs to the TOP6A protein family. Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPO11
Key Reference: Lin,C.S., (2008) Eur. J. Endocrinol. 158 (1), 107-115
Molecular Weight: 44kDa
Peptide Sequence: Synthetic peptide located within the following region:
KFSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Meiotic recombination protein SPO11
Protein Size: 396
Purification: Affinity Purified