Clone Name: MSVA-870R
Product Description: This antibody was validated on 76 different Normal and cancerTissues by IHC-P.
Application Note: IHC-P: 1:75-1:150. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 70
Positive Control: Tonsil: A large fraction of the lymphocytes in the interfollicular areas and few lymphocytes in the germinal centres should show a strong ZAP70 immunostaining.
Negative Control: Tonsil: ZAP70 immunostaining should be absent in epithelial tissues and the majority of cells in germinal centres.
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot ID: P43403
Antigen Species: Human
Immunogen: Recombinant fragment (around aa 247-382) ofhuman ZAP70 protein
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: zeta chain of T cell receptor associated protein kinase 70
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