Formulation: A solution in ethanol
Formal Name: 10-[(2R,3S)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-5Z,8Z-decadienoic acid
Purity: ≥95%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 365
CAS Number: 123931-38-4
Notes: 11R(12S)-EET is an oxylipin and a metabolite of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{39722,52397} It is selectively formed from arachidonic acid by the cytochrome P450 (CYP) isoform CYP2C23 and CYP2C24 over CYP2B2, as well as CYP2C8 over CYP2C9. 11R(12S)-EET (50 nM) activates large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat coronary small arterial smooth muscle cells and binds to isolated guinea pig monocytes in a competitive binding assay using [3H]14(15)-EET (Ki = 595.1 nM).{52399,52398} It inhibits the epithelial sodium channel (ENaC) in a patch-clamp assay using isolated rat cortical collecting duct tubules when used at a concentration of 100 nM.{72332} 11R(12S)-EET induces dilation of precontracted isolated canine epicardial arterioles (EC50 = 6.3 pM) and denuded porcine subepicardial arterioles (EC50 = 1.6 pM).{52399} It induces migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 5 µM.{72333}
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