Formulation: A neat liquid
Formal Name: 3-butylidene-1(3H)-isobenzofuranone
Purity: ≥98%
Formula Markup: C12H12O2
Formula Weight: 188,2
Shelf life (days): 730
CAS Number: 551-08-6
Notes: 3-Butylidenephthalide is a plant metabolite that has been found in L. jeholense and has diverse biological activities.{62715,62716,62717,62714} 3-Butylidenephthalide (60 µg/ml) induces apoptosis and inhibits migration and the epithelial-to-mesenchymal transition (EMT) in 5637, BFTC-905, T24, and TCCSUP human bladder cancer cells.{62715} In vivo, 3-butylidenephthalide (100 and 200 mg/kg) reduces tumor volume in a BFTC-905 mouse xenograft model. 3-Butylidenephthalide (400 mg/kg) increases life span and reduces spinal motor neuron loss in an SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS).{62716} It also reduces undegradable polyglutamine (polyQ) accumulation and cerebral atrophy, as well as improves motor coordination in a mouse model of spinocerebellar ataxia type 3 (SCA3), effects that can be reversed by the autophagy inhibitors bafilomycin A1 (Item No. 11038) and wortmannin (Item No. 10010591).{62717}
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