2-Ketoglutaric acid-13C2, CAS 123953-28-6

Product Description: 2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

Formula: C3 13C2H6O5

References: [1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35./[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662./[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

CAS Number: 123953-28-6

Molecular Weight: 148.08

Research Area: Others

Target: Endogenous Metabolite;Isotope-Labeled Compounds;Tyrosinase

• SKU: MEXHY-W013636S4-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W013636S4-0
• Package Unit: Get quote
• Quantity Unit: STK