2-Ketoglutaric acid-d4, CAS 1381759-60-9

Product Description: 2-Ketoglutaric acid-d4 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C5H2D4O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35./[3]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662.

CAS Number: 1381759-60-9

Molecular Weight: 150.12

Compound Purity: 93.10

Research Area: Others

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Tyrosinase

• SKU: MEXHY-W013636S1-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W013636S1-1
• Package Unit: 1 mg
• Quantity Unit: STK