4'-Hydroxy diclofenac-13C6, CAS 1189656-64-1

Product Description: 4'-Hydroxy diclofenac-13C6 is the 13C labeled 4'-Hydroxy diclofenac[1]. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C8 13C6H11Cl2NO3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8./[3]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar43(3):309-16.

CAS Number: 1189656-64-1

Molecular Weight: 318.10

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Drug Metabolite

• SKU: MEXHY-15550S1-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15550S1-1
• Package Unit: 1 mg
• Quantity Unit: STK