4-Hydroxytolbutamide-d9, CAS 1185112-19-9

Product Description: 4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

Formula: C12H9D9N2O4S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2] Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71./[3]Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

CAS Number: 1185112-19-9

Molecular Weight: 295.40

Compound Purity: 99.29

Research Area: Cancer; Metabolic Disease

Solubility: Ethanol : 12 mg/mL (ultrasonic;warming)

Target: Autophagy;Potassium Channel

• SKU: MEXHY-100641S-500UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100641S-500UG
• Package Unit: 500 μg
• Quantity Unit: STK