α-Hydroxyglutaric acid-d4 (disodium), CAS 2483831-91-8

Product Description: α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

Applications: Cancer-programmed cell death

Formula: C5H2D4Na2O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

CAS Number: 2483831-91-8

Molecular Weight: 196.10

Research Area: Cancer

Solubility: H2O : 125 mg/mL (ultrasonic;warming)

Target: Endogenous Metabolite;Histone Demethylase

• SKU: MEXHY-113038AS1-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-113038AS1-1
• Package Unit: 1 mg
• Quantity Unit: STK