Product Description: Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].
Formula: C23H19D8Cl2N3O2
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20./[3]Burris KD, Molski TF, Xu C et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9./[4]Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36./[5]Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T.
Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T.
Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier.
Biopharm Drug Dispos. 2012 Jul 27. doi: 10.1002/bdd.1801.
CAS Number: 1089115-04-7
Molecular Weight: 456.43
Compound Purity: 99.86
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: 5-HT Receptor;Isotope-Labeled Compounds
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