Product Description: Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C4H2D4N2O2
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769./[3]Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744.
CAS Number: 334473-41-5
Molecular Weight: 118.13
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite;Isotope-Labeled Compounds
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