Product Description: Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride)[1]. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[2][3][4][5][6][7].
Formula: C11H11D7ClNO3
References: [1]Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-K<sub>m</sub> cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7/[2]Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30./[3]M E Conolly, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol/[4]Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35./[5]Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8./[6]Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700./[7]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
CAS Number: 2517584-04-0
Molecular Weight: 254.76
Research Area: Cardiovascular Disease
Target: Adrenergic Receptor;Endogenous Metabolite;Isotope-Labeled Compounds
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