Product Description: L-Leucine-15N,d10 is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Applications: Metabolism-sugar/lipid metabolism
Formula: C6H3D10 15NO2
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857./[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 229(1):77./[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb61(2):409-17.
Molecular Weight: 142.23
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite;mTOR
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