Product Description: Menthofuran-13C2 is 13C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C8 13C2H14O
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Gordon WP, et al. The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran. Drug Metab Dispos. 1987 Sep-Oct;15(5):589-94. /[3]Mahmoud SS, et al. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14481-6.
Molecular Weight: 152.20
Research Area: Others
Solubility: 10 mM in DMSO
Target: Drug Metabolite;Isotope-Labeled Compounds
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