N-Ethylmaleimide-d5, CAS 360768-37-2

N-Ethylmaleimide-d5, CAS 360768-37-2
SKU
MEXHY-D0843S-5
Packaging Unit
5 mg
Manufacturer
MedChemExpress

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Product Description: N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

Formula: C6H2D5NO2

References: [1]Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9./[2]Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15./[3]Choo YS, et al. Detection of protein ubiquitination. J Vis Exp. 2009;(30):1293. Published 2009 Aug 19. doi:10.3791/1293/[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 360768-37-2

Molecular Weight: 130.16

Compound Purity: 99.49

Research Area: Others

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Cathepsin;Deubiquitinase
More Information
SKU MEXHY-D0843S-5
Manufacturer MedChemExpress
Manufacturer SKU HY-D0843S-5
Green Labware No
Package Unit 5 mg
Quantity Unit STK
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