Perindoprilat-d3 (disodium)

Product Description: Perindoprilat-d3 disodium is deuterated labeled Perindoprilat (HY-B1433). Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C17H23D3N2Na2O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Izabella Z A Pawluczyk, et al. The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells. Kidney Int. 2004 Apr;65(4):1240-51./[3]Perindopril. Expert Opin Pharmacother. 2006 Jan;7(1):63-71./[4]X-Z Wang, et al. Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23(15):6672-6682./[5]Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6.

Molecular Weight: 387.40

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Angiotensin-converting Enzyme (ACE);Isotope-Labeled Compounds

• SKU: MEXHY-B1433S-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-B1433S-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK