Regorafénib N-oxyde-d3 (M2), CAS 1333489-03-4

Product Description: Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].

Applications: Cancer-Kinase/protease

Formula: C21H12D3ClF4N4O4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.

CAS Number: 1333489-03-4

Molecular Weight: 501.83

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Drug Metabolite;PDGFR

• SKU: MEXHY-I0678S-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-I0678S-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK