Simvastatin acid-d9 (ammonium)

Product Description: Simvastatin acid-d9 ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

Applications: COVID-19-immunoregulation

Formula: C24H32D9NO6

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272./[3]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165.

Molecular Weight: 448.64

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: HMG-CoA Reductase (HMGCR);Isotope-Labeled Compounds;Reactive Oxygen Species

• SKU: MEXHY-119695AS1-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-119695AS1-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK