Product Description: Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
Applications: Cancer-programmed cell death
Formula: C13H6D4N2O4
References: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53./[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.
CAS Number: 1219177-18-0
Molecular Weight: 262.25
Compound Purity: 98.03
Research Area: Cancer; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Apoptosis;Autophagy;Ligands for E3 Ligase;Molecular Glues
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