Thymine-d4-1, CAS 156054-85-2

Product Description: Thymine-d4-1 is the deuterium labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C5H2D4N2O2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.

CAS Number: 156054-85-2

Molecular Weight: 130.14

Compound Purity: 94.40

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite

• SKU: MEXHY-W010450S4-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W010450S4-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK