Product Description: Zafirlukast-d6 is deuterated labeled Zafirlukast (HY-17492). Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
Applications: COVID-19-immunoregulation
Formula: C31H27D6N3O6S
References: [1]Lei C, et al. Zafirlukast attenuates advanced glycation end-products (AGEs)-induced degradation of articular extracellular matrix (ECM). Int Immunopharmacol. 2019;68:68-73./[2]Finnerty JP, et al. Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D<sub>4</sub> receptor antagonist. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):746-9./[3]Gunning WT, et al. Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res. 2002 Aug 1;62(15):4199-201./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
CAS Number: 1109278-84-3
Molecular Weight: 581.71
Research Area: Cancer; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Isotope-Labeled Compounds;Leukotriene Receptor
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