3-Morpholinosydnonimine, CAS 33876-97-0

Product Description: 3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation[1][2].

Applications: Cancer-Kinase/protease

Formula: C6H10N4O2

References: [1]He Y, et al. 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. Biomed Pharmacother. 2018 Oct;106:1696-1704. /[2]Kaji T, et al. 3-Morpholinosydnonimine hydrochloride induces p53-dependent apoptosis in murine primary neural cells: a critical role for p21(ras)-MAPK-p19(ARF) pathway. Nitric Oxide. 2002 Mar;6(2):125-34.

CAS Number: 33876-97-0

Molecular Weight: 170.17

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: MDM-2/p53

• SKU: MEXHY-126849-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-126849-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK