Product Description: 5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue[1][2][3].
Formula: C27H46O2
References: [1]Pulfer M K, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant[J]. Journal of Biological Chemistry, 2004, 279(25): 26331-26338./[2]Aringer L, et al. Formation and metabolism in vitro of 5, 6-epoxides of cholesterol and 尾-sitosterol[J]. Journal of Lipid Research, 1974, 15(4): 389-398./[3]Garcia-Cruset S, et al. Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions. Free Radic Res. 2001 Jul;35(1):31-41.
CAS Number: 4025-59-6
Molecular Weight: 402.65
Compound Purity: 99.0
Research Area: Others
Solubility: Ethanol : 20 mg/mL (ultrasonic;warming)
Target: Biochemical Assay Reagents
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