Diphtheria Toxin CRM197 mutant from Corynebacterium diphtheriae

Formulation: Each vial, when reconstituted to 0.25 ml with water, contains 250 µg of diphtheria toxin CRM197 mutant in 0.01 M sodium phosphate with 5% lactose at pH 7.4

Purity: ≥90% (estimated by SDS-PAGE)

Shelf life (days): 730

Notes: Diphtheria toxin CRM197 mutant from C. diphtheriae is an inactive and non-toxic version of diphtheria toxin (Item No. 19657). It contains a single base change in the structural gene resulting in the substitution of glutamic acid for glycine which blocks ADP-ribosylation.{38537} Diphtheria toxin CRM197 mutant has no enzymatic activity but is immunologically indistinguishable from diphtheria toxin. Formulations containing diphtheria toxin CRM197 mutant have been used as carriers of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens.{38538}

• SKU: CAY23218
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 23218-250
• Green Labware: No
• Package Unit: 250 µg
• Quantity Unit: STK