Product Description: ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer[1][2][3][4].
Applications: COVID-19-immunoregulation
Formula: (C6H12N2O.ClH)n
References: [1]Wang Z, et al. Metabolomic Analysis of Biosynthesis Mechanism of ε-Polylysine Produced by Streptomyces diastatochromogenes. Front Bioeng Biotechnol. 2021 Jul 30;9:698022./[2]Alemán A, et al. A novel functional wrapping design by complexation of ε-polylysine with liposomes entrapping bioactive peptides[J]. Food and Bioprocess Technology, 2016, 9: 1113-1124./[3]Yingying M, et al. pH-Sensitive ε-polylysine/polyaspartic acid/zein nanofiber membranes for the targeted release of polyphenols. Food Funct. 2022 Jun 20;13(12):6792-6801./[4]Zhou X, et al. Elaboration and characterization of ε-polylysine‑sodium alginate nanoparticles for sustained antimicrobial activity. Int J Biol Macromol. 2023 Aug 16;251:126329.
Molecular Weight: 2000-5000
Research Area: Infection
Solubility: 10 mM in DMSO
Target: Bacterial
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